Crnic L S, Chase H P
Dev Neurosci. 1980;3(2):49-58. doi: 10.1159/000112376.
The effects of six different methods for producing infantile malnutrition in rats upon brain lipid composition at 20 days of age were examined. The methods for producing malnutrition were: (1) large litters were fostered on the dams; (2) dams were fed a low-protein diet; (3) dams were fed an inadequate amount of a good quality diet; (4) pups were removed from the dams for half of each day and kept with a nonlactating female; (5) pups were removed from the dams for half of each day and kept in an incubator; (6) 7 of each dam's 12 teats were destroyed. Although total amounts of lipid were reduced in proportion to the reduction in brain weight by all of the methods, the methods varied as to the lipid components affected and in the extent of the deficits. We conclude that part of the lack of agreement between studies in this area of research is due to the variety in the methods used to produce malnutrition.
研究了六种在大鼠中制造婴儿营养不良的不同方法对20日龄幼鼠脑脂质成分的影响。制造营养不良的方法如下：（1）将大窝幼崽寄养在母鼠身上；（2）给母鼠喂食低蛋白饮食；（3）给母鼠喂食质量好但量不足的饮食；（4）每天将幼崽从母鼠身边带走半天，并与一只未哺乳的雌鼠待在一起；（5）每天将幼崽从母鼠身边带走半天，并放在孵化器中；（6）破坏每只母鼠12个乳头中的7个。尽管所有方法都使脂质总量与脑重量的减少成比例降低，但不同方法对受影响的脂质成分以及缺乏程度有所不同。我们得出结论，该研究领域中各项研究之间缺乏一致性的部分原因在于用于制造营养不良的方法各不相同。
