通过给予N-甲基-N-亚硝基脲（MNU）在裸鼠中诱导胸腺外淋巴白血病。
Induction of extra-thymic lymphatic leukemias in nude mice by means of administration of N-methyl-N-nitrosourea (MNU).
作者信息
Arnold W, Naundorf H, Fey F
出版信息
Exp Pathol (Jena). 1980;18(6):336-40. doi: 10.1016/s0014-4908(80)80023-8.
PMID:7418778
Abstract
Experiments concerning the chemical leukemogenesis in nude mice were performed. Following administration of N-methyl-N-nitrosourea (MNU) 4 out of 11 nude mice developed extra-thymic lymphatic leukemias. The findings are demonstrated by means of histological and histochemical methods. The successful cellular transplantation of an induced lymphatic leukemia is reported.
摘要
开展了关于裸鼠化学性白血病生成的实验。给予N-甲基-N-亚硝基脲（MNU）后，11只裸鼠中有4只发生了胸腺外淋巴白血病。通过组织学和组织化学方法证实了这些发现。报道了诱导性淋巴白血病细胞移植成功的情况。
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