Korcáková L, Holub M, Nouza K, Dráber P
Folia Biol (Praha). 1980;26(3):176-87.
The response of leucocytes to an intraperitoneal injection of sheep red blood cells was investigated in normal (+/+) mice, athymic (nu/nu) mice and their hybrids (nu/+). In +/+ mice (in addition to a non-specific decrease in the number of granulocytes in the first 6 h after injection) the leucocyte levels were below the initial levels almost throughout the experiment (12 days). This was due mainly to lymphocytopenia. In nu/+ and nu/nu mice a marked leucocytosis developed, due mainly to the increased numbers of lymphocytes. The response of lymphocytes estimated by the morphological appearance of nucleoli showed an increase in numbers of both active lymphocytes with RNA-synthesizing nucleoli and terminal lymphocytes with micronucleoli.
研究了正常（+/+）小鼠、无胸腺（nu/nu）小鼠及其杂种（nu/+）小鼠对腹腔注射绵羊红细胞的白细胞反应。在+/+小鼠中（除注射后最初6小时粒细胞数量出现非特异性减少外），白细胞水平在整个实验期间（12天）几乎都低于初始水平。这主要是由于淋巴细胞减少所致。在nu/+和nu/nu小鼠中，出现了明显的白细胞增多，主要是由于淋巴细胞数量增加。通过核仁的形态外观评估的淋巴细胞反应显示，具有RNA合成核仁的活性淋巴细胞和具有微核仁的终末淋巴细胞数量均增加。
