Miyasaka M, Takiguchi T, Konda S
Gan. 1980 Jun;71(3):293-9.
The effect of thioglycollate-induced macrophages on the growth of syngeneic B16 melanoma cells was studied. Thioglycollate-induced macrophages showed strong cytostasis and cytotoxicity towards B16 tumor cells in vitro. However, these effects were not demonstrable in an in vivo assay which involved local transfer and experimental metastasis. In contrast to the in vitro results, mice injected iv with both B16 tumor cells alone. Possible reasons for the failure of thioglycollate-induced macrophages to exhibit cytostatic and cytotoxic activity in vivo are discussed.
研究了巯基乙酸盐诱导的巨噬细胞对同基因B16黑色素瘤细胞生长的影响。巯基乙酸盐诱导的巨噬细胞在体外对B16肿瘤细胞表现出强烈的细胞抑制和细胞毒性。然而，在涉及局部转移和实验性转移的体内试验中，这些作用并未得到证实。与体外结果相反，单独静脉注射B16肿瘤细胞的小鼠……讨论了巯基乙酸盐诱导的巨噬细胞在体内未能表现出细胞抑制和细胞毒性活性的可能原因。
