Koura M, Isaka H
Gan. 1980 Jun;71(3):313-8.
A human adenocarcinoma cell line was successfully established from the lymph-node metastasis of transverse colon cancer. Primary culture was done with the tumor developed in a nude mouse which had been inoculated with the metastatic lymph node. Morphological characteristics, growth kinetics, chromosomes, tumorigenicity and high production of carcinoembryonic antigen by the established cells are described. This cell line should be a useful tool for studies on the mechanism of re-expression of the fetal gene which is responsible for carcinoembryonic antigen expression in colon cancer cells.
从横结肠癌的淋巴结转移灶中成功建立了一株人腺癌细胞系。采用接种有转移淋巴结的裸鼠体内生长的肿瘤进行原代培养。描述了所建细胞系的形态特征、生长动力学、染色体、致瘤性以及癌胚抗原的高表达情况。该细胞系应是研究结肠癌中负责癌胚抗原表达的胎儿基因重新表达机制的有用工具。
