Paterok E M, Weishaar J, Bischoff J, Müller D
Geburtshilfe Frauenheilkd. 1980 Sep;40(9):755-60. doi: 10.1055/s-2008-1039328.
From 1976 to 1978 11, 197 women were examined clinically and mammographically. Biopsy material from 1,673 breasts were examined microscopically. In 536 cases, or almost every third case (32%), a carcinoma of the breast was detected. The cancer was bilateral in 19 cases and the total number of women was therefore 517. A clinically occult tumour was only found in 7.7% (40 of 517) of the cases. 5% of these patients were high risk patients and 2.7% preventive examinations. 5 women with occult carcinoma of the breast were under age 40 and 14 under age 50. Benign changes of the glandular tissue were found in 59.5% of the cases. Marked proliferative changes were found in 4.6% of the cases and carcinoma in situ was found in 3.8% of the patients. In the age group 45--54 benign and proliferative changes of the parenchyma occured almost twice as often as cancers. The ratio between benign and malignant findings was 1:1 in the age group 55--59 and was less than 1:2 in the age group over 70. A sophistication of the mammograhic technique must be obtained. A thorough microscopic examination of tissue from subcutaneous mastectomies and tissue obtained at the time of reduction mammoplasties showed occasionally unexpected malignant tissue in an unexpected location. Especially these cases are suitable for later comparison to the mammographies.
1976年至1978年期间,对11197名女性进行了临床检查和乳房X光检查。对1673例乳房的活检材料进行了显微镜检查。在536例病例中,即几乎每三例中就有一例(32%)检测出乳腺癌。其中19例为双侧乳腺癌,因此女性患者总数为517名。仅在7.7%(517例中的40例)的病例中发现了临床隐匿性肿瘤。这些患者中有5%为高危患者,2.7%为预防性检查对象。5例隐匿性乳腺癌患者年龄在40岁以下,14例在50岁以下。59.5%的病例发现了腺组织的良性改变。4.6%的病例发现了明显的增生性改变,3.8%的患者发现了原位癌。在45 - 54岁年龄组中,实质的良性和增生性改变的发生率几乎是癌症的两倍。在55 - 59岁年龄组中,良性与恶性发现的比例为1:1,在70岁以上年龄组中该比例小于1:2。必须提高乳房X光检查技术的精密程度。对皮下乳房切除术的组织以及在乳房缩小整形术时获取的组织进行全面的显微镜检查,偶尔会在意外位置发现意外的恶性组织。特别是这些病例适合以后与乳房X光检查结果进行对比。