Weitzman R E, Leake R D, Rubin R T, Fisher D A
J Clin Endocrinol Metab. 1980 Oct;51(4):836-9. doi: 10.1210/jcem-51-4-836.
The effect of nursing on plasma levels of oxytocin (OT), arginine vasopressin (AVP), and PRL was studied in six normal women 2-3 days post partum. Maternal blood samples were obtained for measurement of OT, AVP, PRL, sodium, and osmolality 3 and 0 min before suckling, at 3-min intervals for 15 min during suckling, and 5 min after completion of suckling. Plasma OT rose during suckling from a mean (+/- SEM) baseline value of 1.1 +/- 0.2 to 3.6 +/- 0.6 microU/ml by 3 min (P < 0.001), reached a peak level of 6.4 +/- 1.5 microU/ml by 6 min (P < 0.005), and remained elevated for the entire 15-min period of suckling. Serial measurements of plasma OT during suckling failed to show a pattern consistent with episodic secretion. The baseline plasma AVP concentration was 0.4 +/- 0.1 microU/ml and was not significantly altered by suckling. Plasma sodium and osmolality remained unchanged during the suckling period. The baseline serum PRL level was 268 +/- 24 ng/ml and rose to 362 +/- 31 ng/ml after 15 min of suckling (P < 0.05). The data suggest that suckling is a specific stimulus for OT and PRL secretion but has no effect on AVP release.
研究了护理对6名产后2 - 3天正常女性血浆中催产素（OT）、精氨酸加压素（AVP）和催乳素（PRL）水平的影响。在哺乳前3分钟和0分钟、哺乳期间每隔3分钟共15分钟以及哺乳结束后5分钟采集母体血样，用于测量OT、AVP、PRL、钠和渗透压。哺乳期间血浆OT从平均（±标准误）基线值1.1±0.2微单位/毫升在3分钟时升至3.6±0.6微单位/毫升（P<0.001），在6分钟时达到峰值6.4±1.5微单位/毫升（P<0.005），并在整个15分钟的哺乳期间保持升高。哺乳期间血浆OT的系列测量未显示出与阵发性分泌一致的模式。血浆AVP的基线浓度为0.4±0.1微单位/毫升，哺乳对其无显著影响。哺乳期间血浆钠和渗透压保持不变。血清PRL的基线水平为268±24纳克/毫升，哺乳15分钟后升至362±31纳克/毫升（P<0.05）。数据表明，哺乳是OT和PRL分泌的特定刺激因素，但对AVP释放无影响。
