Franklin E C
J Allergy Clin Immunol. 1980 Oct;66(4):269-73. doi: 10.1016/0091-6749(80)90020-2.
Immune complexes play a major role in a variety of diseases such as lupus and rheumatoid arthritis. Cryoglobulins, especially those of the mixed type, represent a type of immune complex that is particularly easy to isolate, and hence lend themselves readily to the identification of the responsible precipitating agents. This report presents the clinical, laboratory, and pathologic features of 40 patients with mixed cryoglobulinemia and offers some speculation based on currently available evidence on the role of cryoglobulins in pathogenesis.
免疫复合物在多种疾病中起主要作用，如狼疮和类风湿性关节炎。冷球蛋白，尤其是混合型冷球蛋白，是一种特别容易分离的免疫复合物，因此很容易用于鉴定相关的沉淀剂。本报告介绍了40例混合型冷球蛋白血症患者的临床、实验室和病理特征，并根据目前关于冷球蛋白在发病机制中作用的现有证据进行了一些推测。
