Eu H, Jasmin G, Coërs C, Telerman-Toppet N
J Neurol Sci. 1980 Sep;47(3):329-41. doi: 10.1016/0022-510x(80)90086-6.
Terminal motor innervation and the histochemical profile of muscle fibers were investigated, before and after sciatic nerve crushing, in 1- to 150-day-old myopathic hamsters. The observed morphologic abnormalities in terminal motor innervation were of varying degree prior to the nerve injury. These abnormalities were found in close proximity to lesions of the myofibers, and became more pronounced with age and the progression of the disease process. Collateral ramification of healthy axons occurred in hamsters of 120 days of age with reinnervation of damaged muscle fibers. When submitted to sciatic nerve crushing, myopathic hamsters showed an ability to regenerate and reinnervate the subneural apparatuses. The regenerative process in these animals was essentially the same as in normal, sciatic nerve-crushed hamsters. Thus, it was concluded that the morphologic changes in terminal motor innervation were secondary to muscle cell degeneration.
在1至150日龄的肌病性仓鼠中，研究了坐骨神经挤压前后的终末运动神经支配及肌纤维的组织化学特征。在神经损伤之前，观察到的终末运动神经支配的形态学异常程度各异。这些异常出现在肌纤维病变附近，并且随着年龄增长和疾病进程的发展而变得更加明显。120日龄的仓鼠出现健康轴突的侧支分支，受损肌纤维得以重新神经支配。当遭受坐骨神经挤压时，肌病性仓鼠表现出再生并重新支配神经下装置的能力。这些动物的再生过程与正常的、坐骨神经挤压的仓鼠基本相同。因此，得出结论，终末运动神经支配的形态学变化是肌肉细胞变性的继发结果。
