Gelbard A S, Benua R S, Reiman R E, McDonald J M, Vomero J J, Laughlin J S
J Nucl Med. 1980 Oct;21(10):988-91.
In normal volunteers and cancer patients, studies using L-(N-13)glutamate as an imaging agent showed localization of N-13 activity in the heart. Other organs that were well visualized include the liver, pancreas, and salivary glands. In ten subjects the average myocardial uptake after intravenous injection of labeled glutamate was (5.7 +/- 0.39)% (s.e.m.) of injected dose, as determined by a quantitative scanning system. The concentration of N-13 activity in the human heart could not be predicted from previous studies involving myocardial uptake in dogs and rodents after administration of L-(N-13)glutamate.
在正常志愿者和癌症患者中，使用L-(N-13)谷氨酸作为成像剂的研究显示，N-13活性定位于心脏。其他显影良好的器官包括肝脏、胰腺和唾液腺。通过定量扫描系统测定，在10名受试者中，静脉注射标记谷氨酸后心肌的平均摄取量为注射剂量的(5.7±0.39)%（标准误）。根据先前关于犬类和啮齿动物在给予L-(N-13)谷氨酸后心肌摄取的研究，无法预测人心脏中N-13活性的浓度。
