Kubota K, Fukuda H, Yamada K, Endo S, Ito M, Abe Y, Yamaguchi T, Fujiwara T, Sato T, Yamaura H
Eur J Nucl Med. 1983;8(12):528-30. doi: 10.1007/BF00251614.
Accumulation of 13N-L-glutamate in the pancreas was experimentally evaluated by tissue distribution studies and by positron computer tomography imaging studies. The pancreas and salivary gland of Donryu rats exhibited a high rate of 13N-glutamate uptake. The percent administered dose/g of pancreas was 3.8 at 20 min, 4.4 at 30 min after injection, and the pancreas to liver ratio was 1.9 and 2.5, respectively. The same results were obtained with Golden hamsters. The role of the feeding protocols was studied to optimize the technique. The fasting group showed a significantly higher uptake in the pancreas than in the free feeding group. The uptake in the fasting followed by a high protein meal group was higher than fasting only group, but the difference was not significant. Positron emission tomography of a miniature-pig with 13N-glutamate showed a clear image of the pancreas with the highest activity. It was concluded that 13N-glutamate was quite useful in positron imaging of the pancreas.
通过组织分布研究和正电子计算机断层扫描成像研究，对胰腺中(^{13}N - L -)谷氨酸的蓄积进行了实验评估。唐育大鼠的胰腺和唾液腺表现出较高的(^{13}N -)谷氨酸摄取率。注射后20分钟时，胰腺每克组织摄取的给药剂量百分比为3.8%，30分钟时为4.4%，胰腺与肝脏的比值分别为1.9和2.5。金黄仓鼠也得到了相同的结果。研究了喂养方案的作用以优化该技术。禁食组胰腺的摄取率明显高于自由进食组。禁食后高蛋白饮食组的摄取率高于仅禁食组，但差异不显著。用(^{13}N -)谷氨酸对小型猪进行正电子发射断层扫描，显示出胰腺的清晰图像，其活性最高。得出的结论是，(^{13}N -)谷氨酸在胰腺的正电子成像中非常有用。
