4-[对-[双(2-氯乙基)氨基]苯基]丁酸酯的合成及其抗肿瘤活性
Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates.
作者信息
Roehrig G R, Billman J H, Marcec J, Fritz P, Shea F
出版信息
J Pharm Sci. 1980 Oct;69(10):1232-4.
PMID:7420301
Abstract
Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.
摘要
合成了十种4-[对-[双(2-氯乙基)氨基]苯基]丁酸酯，并对其抗肿瘤活性进行了评估。在初步筛选试验中，2-苯氧乙基酯对P-388淋巴细胞白血病表现出活性，正丁酯和正戊酯对L-1210淋巴白血病表现出活性。
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