强效铁螯合剂N1,N8-双(2,3-二羟基苯甲酰基)亚精胺的合成、吸收及毒性
Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator.
作者信息
Bergeron R J, Burton P S, McGovern K A, St Onge E J, Streiff R R
出版信息
J Med Chem. 1980 Oct;23(10):1130-3. doi: 10.1021/jm00184a013.
PMID:7420358
Abstract
A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator.
摘要
以N4-苄基亚精胺为起始原料，合成了一种有效的铁螯合剂N1,N8-双(2,3-二羟基苯甲酰基)亚精胺。对该化合物的毒性和吸收特性进行了评估，进一步证明了其作为临床铁螯合剂的潜力。
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