儿茶酚胺铁螯合剂的抑菌和抑真菌作用。
Bacteriostatic and fungostatic action of catecholamide iron chelators.
作者信息
Bergeron R J, Elliott G T, Kline S J, Ramphal R, St James L
出版信息
Antimicrob Agents Chemother. 1983 Nov;24(5):725-30. doi: 10.1128/AAC.24.5.725.
Abstract
Iron starvation as a means of controlling the proliferation of microorganisms was evaluated in vitro with spermidine catecholamide iron chelators. The growth of Escherichia coli and Pseudomonas aeruginosa was sensitive only to (D,L)-parabactin, whereas the growth of Candida albicans and Staphylococcus aureus was sensitive to a variety of catecholamide chelators. The disappearance of catecholamide activity upon methylation of the catechol hydroxyls, as well as iron reversal experiments, strongly suggests that the mechanism by which these compounds suppress growth is dependent upon their ability to sequester iron.
摘要
利用亚精胺儿茶酚胺铁螯合剂在体外评估了铁饥饿作为控制微生物增殖手段的效果。大肠杆菌和铜绿假单胞菌的生长仅对（D，L）-副杆菌素敏感，而白色念珠菌和金黄色葡萄球菌的生长对多种儿茶酚胺螯合剂敏感。儿茶酚羟基甲基化后儿茶酚胺活性的消失以及铁逆转实验强烈表明，这些化合物抑制生长的机制取决于它们螯合铁的能力。
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