Simon M R, Weinstock J V, Kataria Y P
J Clin Lab Immunol. 1980 May;3(3):175-8.
In vitro lymphocyte thymidine uptake in response to validated Kveim antigen CR-1 was studied in 18 patients with Crohn's disease and in 30 of their household contacts. Two of the patients and 3 of the contacts demonstrated a stimulation index of 2 or greater. None of 15 control subjects demonstrated such reactivity. Lymphocytes from patient and household contact groups exhibited a greater mean increment in cpm than those from the control group (110, 130 and 33 cpm, respectively) (p < 0.05 and p < 0.005, respectively). This finding indicates a low level of lymphocyte reactivity to Kveim antigen in patients and in contacts, suggesting sensitization to Kveim antigen or to a cross-reacting antigen.
在18例克罗恩病患者及其30名家庭接触者中，研究了体外淋巴细胞对经过验证的克维姆抗原CR-1的胸腺嘧啶核苷摄取情况。2例患者和3名接触者的刺激指数为2或更高。15名对照受试者均未表现出这种反应性。患者组和家庭接触者组的淋巴细胞每分钟计数平均增加量高于对照组（分别为110、130和33 cpm）（分别为p < 0.05和p < 0.005）。这一发现表明患者及其接触者对克维姆抗原的淋巴细胞反应性较低，提示对克维姆抗原或交叉反应抗原致敏。
