Shamasunder H K, Gregory S A, Knospe W H
JAMA. 1980 Sep 26;244(13):1454-5.
Uracil mustard was used for the treatment of thrombocytosis in 14 patients, eight who had polycythemia vera and six who had essential thrombocytosis. Intermittent treatment with 1 to 2 mg/day for 14 days was used for most patients, and continuous treatment was used for three patients. The nadir of the platelet count occurred during a mean period of five to seven weeks, and the mean duration between courses was seven months. The drug selectively depressed the platelet count, with a minimal effect on leukocytes and erythrocytes. Uracil mustard is an effective drug for the control of thrombocytosis.
尿嘧啶氮芥用于治疗14例血小板增多症患者，其中8例为真性红细胞增多症，6例为原发性血小板增多症。大多数患者采用每日1至2毫克、持续14天的间歇治疗，3例患者采用持续治疗。血小板计数最低点出现在平均五至七周期间，疗程之间的平均间隔为七个月。该药物选择性地降低血小板计数，对白细胞和红细胞影响极小。尿嘧啶氮芥是控制血小板增多症的有效药物。
