[纤维蛋白原及其蛋白水解片段温度转变的微量热研究]
[Microcalorimetric studies of temperature transitions in fibrinogen and its proteolytic fragments].
作者信息
Medved' L V, Tiktopulo E I, Privalov P L, Varetskaia G V
出版信息
Mol Biol (Mosk). 1980 Jul-Aug;14(4):835-42.
Melting of fibrinogen and its proteolytic fragments has been studied by differential scanning microcalorimetry. It has been shown that the fibrinogen molecule contains at least nine cooperative regions. One of them pertains to the central structural block (domain E), two of them are formed by the structures removed at proteolytic fragmentation and the others make part of the terminal structural blocks (domains D). A scheme of localization of melting regions in the fibrinogen molecule is proposed on the basis of the results obtained.
利用差示扫描量热法研究了纤维蛋白原及其蛋白水解片段的熔化情况。结果表明，纤维蛋白原分子至少包含九个协同区域。其中一个区域属于中央结构模块（结构域E），两个区域由蛋白水解片段化时去除的结构形成，其他区域则是末端结构模块（结构域D）的一部分。根据所得结果，提出了纤维蛋白原分子中熔化区域的定位示意图。
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