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[关于一例因酒石酸正丙基阿马林所致迅速进展的致命性中毒病例(作者译)]

[On a case of a repidly proceeding lethal intoxication due to n-propylajmalium bitartrate (author's transl].

作者信息

Brettel H F, Schmidt K, Koch U

出版信息

Z Rechtsmed. 1978 Dec 20;82(3):231-6. doi: 10.1007/BF02092340.

Abstract

A case of N-Propylajmalinum bitartrate intoxication (Neo-Gilurytmal) is reported in which the death occurred within 20 minutes after the consumption of the drug. The quantitative estimation of the drug after isolation using Extrelut--columns was carried out in stomach spectrometrically, in the blood, bile, liver, kidney, and brain by gaschromatography after trifluoroacetylation. A high Prajmalium-bitartrate concentration was found in the blood (3,85 mg/l), negative results in bile and brain, low levels in liver (0,29 mg/kg wet weight) and kidney (0,06 mg/kg wet weight). Prajmalium-bitartrate was ingested together with beer, and a blood alcohol concentration of 0.061% was determined. Furthermore, a quantity corresponding to six tablets of Neo-Gilurytmal was still found in the stomach. The rapid fatal progress of the intoxication is explained as a strong effect of the drug on the heart due to the alcohol accelerated resorption of the substance.

摘要

报告了一例酒石酸丙吡胺(新安眠尔通)中毒病例,患者在服用该药物后20分钟内死亡。使用硅酸镁载体柱分离后,通过光谱法对胃中的药物进行定量测定,对血液、胆汁、肝脏、肾脏和大脑中的药物进行三氟乙酰化后用气相色谱法进行测定。血液中发现酒石酸丙吡胺浓度较高(3.85毫克/升),胆汁和大脑中结果为阴性,肝脏(0.29毫克/千克湿重)和肾脏(0.06毫克/千克湿重)中含量较低。酒石酸丙吡胺与啤酒一起摄入,测定血液酒精浓度为0.061%。此外,胃中仍发现相当于六片新安眠尔通的药量。中毒的快速致命进展被解释为由于酒精加速了该物质的吸收,药物对心脏产生了强烈作用。

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