Simonnet G, Bioulac B, Rodriguez F, Vincent J D
Pharmacol Biochem Behav. 1980 Sep;13(3):359-63. doi: 10.1016/0091-3057(80)90239-7.
Angiotensin II (AII) was microiontophoretically applied on neurones located in the septum and the medial preoptic area (MPOA). All the septal neurones sensitive to AII (15/37) responded by an inhibition to the peptide application. Of 44 units tested in the MPOA 21 cells (48%) were sensitive to AII and responded either by an increase (11/21) or decrease (10/21) in their firing. The specificity of these responses were ascertained by simultaneous application of the antagonist Sar-Ile-Angiotensin II. These data suggest that Angiotensin II acts directly on neurones of the septum and medial preoptic area, structures implicated in the control of drinking behaviour.
血管紧张素II（AII）通过微量离子透入法施加于位于隔区和内侧视前区（MPOA）的神经元上。所有对AII敏感的隔区神经元（15/37）在施加该肽时均表现出抑制反应。在MPOA测试的44个单位中，21个细胞（48%）对AII敏感，其放电活动要么增加（11/21），要么减少（10/21）。通过同时应用拮抗剂Sar-Ile-血管紧张素II确定了这些反应的特异性。这些数据表明，血管紧张素II直接作用于隔区和内侧视前区的神经元，这些结构与饮水行为的控制有关。
