El-Banna A A
Prostaglandins. 1980 Sep;20(3):587-99. doi: 10.1016/0090-6980(80)90046-5.
To determine the effective time of indomethacin (Id) action in disrupting early pregnancy, groups of rabbits were treated at various stages after mating with Id and/or replacement doses of PGF2 alpha. Effect of Id on the secretion of uterine proteins was also investigated. The highest rate of embryonic death occurred when Id was injected twice daily during days 5-7 of pregnancy, and days 5-6 appear to be the most critical. Persisting levels of Id during this critical stage is required to induce the antifertility effect. The results also indicate that the adverse effect of Id is not mediated through an effect on uterine proteins, and is mainly due to the inhibition of PG's synthesis. PG's are apparently required for normal implantation and early development.
为确定吲哚美辛（Id）干扰早期妊娠的有效作用时间，将兔分组，在交配后的不同阶段用Id和/或PGF2α替代剂量进行处理。还研究了Id对子宫蛋白分泌的影响。当在妊娠第5 - 7天每天注射两次Id时，胚胎死亡率最高，第5 - 6天似乎最为关键。在此关键阶段持续存在Id水平才能诱导抗生育作用。结果还表明，Id的不良反应不是通过对子宫蛋白的作用介导的，主要是由于抑制了前列腺素（PG）的合成。正常着床和早期发育显然需要PG。
