Hartmann H R, Bollag W
Schweiz Med Wochenschr. 1980 Jul 8;110(27-28):1078-80.
5'-deoxy-5-fluorouridine (5-DFUR) exerts a marked cytostatic activity, both intraperitoneally and orally, against experimental tumors. It has a strong antitumor effect on the Crocker sarcoma S 180, the Lewis lung carcinoma and a chemically induced squamous cell carcinoma of the skin. Its ratio of antitumor activity toxicity is more favourable than that of 5-fluorouracil, 2'-deoxy-5-fluorouridine and 1-(2-tetra-hydrofuryl)-5-fluorouracil. Mode of action and reasons for the favourable therapeutic ratio are discussed.
5'-脱氧-5-氟尿苷（5-DFUR）经腹腔内和口服给药，对实验性肿瘤均具有显著的细胞生长抑制活性。它对克罗克肉瘤S 180、刘易斯肺癌以及化学诱导的皮肤鳞状细胞癌具有很强的抗肿瘤作用。其抗肿瘤活性与毒性之比优于5-氟尿嘧啶、2'-脱氧-5-氟尿苷和1-(2-四氢呋喃基)-5-氟尿嘧啶。文中讨论了其作用方式及治疗指数良好的原因。
