邻苯二甲酸酯对原代培养成纤维细胞的影响。

The effects of phthalate esters on fibroblasts in primary culture.

作者信息

Teranishi H, Kasuya M

出版信息

Toxicol Lett. 1980 Jun;6(1):11-5. doi: 10.1016/0378-4274(80)90094-6.

Abstract

The toxicity of butylbenzyl phthalate(BLP), di-n-heptyl phthalate (DNHP) and n-butyl lauryl phthalate (BLP) to fibroblasts from newborn rat cerebellum in primary culture was significant at concentrations of 7.0, 2.7, and 5.0 x 10(-4) M, respectively. The toxicity of di-methoxyethyl phthalate(DMEP), butyl phthalyl butyl glycolate(BPBG), di-n-octyl phthalate(DNOP), and di-(2-ethylhexyl) phthalate(DEHP) was not significant. Phthalic acid and potassium hydrogen phthalate (K-phthalate) were the least toxic to fibroblasts. Comparison of the toxicity to fibroblasts of five phthalate esters of normal series showed that dimethyl phthalate(DMP) < diethyl phthalate(DEP) < di-n-butyl phthalate(DNBP) > DNHP > DNOP.

摘要

邻苯二甲酸丁苄酯（BLP）、邻苯二甲酸二正庚酯（DNHP）和邻苯二甲酸丁基月桂酯（BLP）对原代培养的新生大鼠小脑成纤维细胞的毒性分别在浓度为7.0、2.7和5.0×10⁻⁴ M时具有显著性。邻苯二甲酸二甲氧基乙酯（DMEP）、邻苯二甲酸丁基丁基乙二醇酯（BPBG）、邻苯二甲酸二正辛酯（DNOP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）的毒性不显著。邻苯二甲酸和邻苯二甲酸氢钾（K-邻苯二甲酸盐）对成纤维细胞的毒性最小。对正常系列的五种邻苯二甲酸酯对成纤维细胞的毒性比较表明，邻苯二甲酸二甲酯（DMP）＜邻苯二甲酸二乙酯（DEP）＜邻苯二甲酸二正丁酯（DNBP）＞DNHP＞DNOP。