邻苯二甲酸丁苄酯（BBP）及其他邻苯二甲酸酯对培养的神经组织的毒性
Toxicity of butylbenzyl phthalate (BBP) and other phthalate esters to nervous tissue in culture.
作者信息
Kasuya M
出版信息
Toxicol Lett. 1980 Oct;6(6):373-8. doi: 10.1016/0378-4274(80)90109-5.
PMID:7444977
Abstract
Butylbenzyl phthalate (BBP) and n-butyl lauryl phthalate (BLP) markedly inhibited the outgrowth of nerve fibers and glial cells from cerebellar explants of newborn rat in primary culture at concentrations of 7.0 and 12.5 x 10(-4) M, respectively. The toxicity of butyl phthalyl butyl glycolate (BPBG) was not significant. From these results the order of toxicity of these three phthalate esters was determined as BBP > BLP > BPBG.
摘要
邻苯二甲酸丁苄酯（BBP）和邻苯二甲酸丁基月桂酯（BLP）分别在浓度为7.0×10⁻⁴ M和12.5×10⁻⁴ M时，显著抑制新生大鼠小脑外植体在原代培养中神经纤维和神经胶质细胞的生长。丁基邻苯二甲酰基丁基甘醇酸酯（BPBG）的毒性不显著。根据这些结果，确定这三种邻苯二甲酸酯的毒性顺序为BBP＞BLP＞BPBG。
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