衰老，加重镉慢性毒性的一个因素。

Ageing, a factor aggravating chronic toxicity of cadmium.

作者信息

Nomiyama K, Nomiyama H, Yotoriyama M

出版信息

Toxicol Lett. 1980 Sep;6(4-5):225-30. doi: 10.1016/0378-4274(80)90123-x.

Abstract

Two groups, each of 4 rabbits, 17 and 4 months old, respectively, were given s.c. administrations of cadmium (Cd) at a dose level of 0.5 mg/kg/day 6 times per week for up to 32 weeks. In 17-month-old rabbits, low-molecular-weight proteinuria appeared in the 3rd week, proteinuria, glycosuria and anemia in the 6th week; and all animals died by the 8th week. In 4-month-old rabbits, low-molecular-weight proteinuria and anemia appeared in the 6th--9th weeks, proteinuria, glycosuria and aminoaciduria by the 12th week; and all animals died by the 32nd week. The results suggest that ageing may aggravate the chronic toxicity of cadmium.

摘要

将两组各4只兔子，分别为17月龄和4月龄，每周皮下注射6次剂量为0.5毫克/千克/天的镉，持续32周。17月龄的兔子在第3周出现低分子量蛋白尿，第6周出现蛋白尿、糖尿和贫血；所有动物在第8周死亡。4月龄的兔子在第6至9周出现低分子量蛋白尿和贫血，第12周出现蛋白尿、糖尿和氨基酸尿；所有动物在第32周死亡。结果表明，衰老可能会加重镉的慢性毒性。