Morselt A F, Broekaert D, Jongstra-Spaapen E J, Copius-Peereboom-Stegeman J H
Arch Toxicol. 1984 Sep;55(3):155-60. doi: 10.1007/BF00316120.
After chronic exposure to low doses of CdCl2 an increase in disulphide bonds has been established in rat liver using a specific staining method for disulphide bonds and cytophotometric quantitation. This increase is dependent on doses and length of exposure time. Evidence is presented that this increase might be related to the accumulation of metallothionein or some other cadmium binding protein. Using the same staining method after long exposure to low doses of CdCl2 a large number of large dark blue stained granules were observed in the proximal tubule cells, with blue stained deposits in the lumen of the proximal and some renal medulla tubules of the kidney. Evidence is presented that this staining pattern corresponds to the destruction of the proximal tubule cell by the cadmium thionein complex.
在大鼠肝脏中，通过使用二硫键特异性染色方法和细胞光度法定量，已证实长期暴露于低剂量的氯化镉后二硫键增加。这种增加取决于剂量和暴露时间的长短。有证据表明，这种增加可能与金属硫蛋白或其他一些镉结合蛋白的积累有关。在长期暴露于低剂量的氯化镉后，使用相同的染色方法，在近端小管细胞中观察到大量深蓝色染色颗粒，在近端小管腔以及肾脏的一些肾髓质小管中也有蓝色染色沉积物。有证据表明，这种染色模式与镉硫蛋白复合物对近端小管细胞的破坏相对应。
