Nikkanen T A, Mäkinen E, Ekfors T O, Hakkarainen S, Drysun B
Strahlentherapie. 1980 Jun;156(6):417-9.
Osteonecrosis of the femoral head developed in two patients with malignant lymphoma treated with combined chemotherapy. Pain was the main symptom. It was not possible to radiographically distinguish the necrotic lesions from metastatic tumour growth, and in both cases only histological examination revealed the true nature of bone destruction. The large doses of corticosteroids included in the treatment regimens were most likely of more importance in the etiology of the necrosis than the cytostatic drugs proper.
两名接受联合化疗的恶性淋巴瘤患者发生了股骨头坏死。疼痛是主要症状。影像学上无法将坏死病变与转移性肿瘤生长区分开来，在这两个病例中，只有组织学检查揭示了骨破坏的真实性质。治疗方案中使用的大剂量皮质类固醇在坏死病因中可能比单纯的细胞毒性药物更为重要。
