正常及升高静水压下大鼠门静脉的自发活动。

Spontaneous activity of rat portal vein at normal and elevated hydrostatic pressure.

作者信息

Sigurdsson S B, Ornhagen H C

出版信息

Undersea Biomed Res. 1980 Sep;7(3):171-81.

Abstract

The effects of high hydrostatic pressure on the spontaneous contractile activity of isolated rat portal veins were studied. During compression, an increase of activity was seen, whereas stable elevated hydrostatic pressure gave a decrease of both frequency and time-integrated force. Decompression further reduced the activity, but all changes were reversible upon return to control pressure. During sustained high pressure the frequency of contractions was reduced by 15.9% at 25 atm, 26.4% at 50 atm, and 45.8% at 100 atm. The corresponding reductions in integrated active force were 13.7%, 16.7%, and 40.7%, respectively. Contractions caused by electrical stimulation of nerve endings left in the preparation were reduced by 44.1%, and potassium contractures were reduced by only 15.3% at 100 atm. It is concluded that inhibition of activity in rat portal vein at high hydrostatic pressure is due in part to effects on the smooth muscle membrane.

摘要

研究了高静水压对离体大鼠门静脉自发收缩活性的影响。在加压过程中，观察到活性增加，而稳定的高静水压则使频率和时间积分力均降低。减压进一步降低了活性，但恢复到对照压力后，所有变化都是可逆的。在持续高压下，收缩频率在25个大气压时降低了15.9%，在50个大气压时降低了26.4%，在100个大气压时降低了45.8%。相应的活性力积分降低分别为13.7%、16.7%和40.7%。在100个大气压时，由制备物中残留的神经末梢电刺激引起的收缩降低了44.1%，钾挛缩仅降低了15.3%。得出结论，高静水压下大鼠门静脉活性的抑制部分归因于对平滑肌膜的影响。