Takano T, Miyazaki Y, Nashimoto I, Kobayashi K
Undersea Biomed Res. 1980 Sep;7(3):191-7.
To evaluate the efficacy of hyperbaric oxygen on cyanide intoxication, changes in the intracellular oxidation-reduction state of the renal cortex were observed in situ in 16 New Zealand white rabbits by detecting the reduced pyridine nucleotide fluorescence that represents the degree of cyanide blockade of the respiratory chain. The data indicated that 100% oxygen at 2 ATA exerted both prophylactic and therapeutic antagonistic effects on the cyanide poisoning. Administration of hyperbaric oxygen could constitute a significant treatment if proper chemical treatment is carried out concomitantly.
为评估高压氧对氰化物中毒的疗效，通过检测代表呼吸链氰化物阻断程度的还原吡啶核苷酸荧光，对16只新西兰白兔的肾皮质细胞内氧化还原状态的变化进行了原位观察。数据表明，2个绝对大气压下的纯氧对氰化物中毒具有预防和治疗拮抗作用。如果同时进行适当的化学治疗，高压氧治疗可能会成为一种重要的治疗方法。
