Drelichman A, Amer M, Pontes E, Al-Sarraf M, Vaitkevicius V K
Urology. 1980 Sep;16(3):250-5. doi: 10.1016/0090-4295(80)90036-9.
Clinically diagnosed breast metastasis from prostatic carcinoma is rare. Primary breast carcinoma in patients with prostatic primary is also uncommon. Four patients who presented with breast malignancies in the course of their prostatic carcinoma are described. All but one of them had diffuse metastatic disease. Three of them were on estrogens at the time breast malignancy was diagnosed. Difficulties always arise in differentiating primary lesions from metastasis clinically and histopathologically. The development of histochemical methods for acid phosphatase, and the newest indirect immunofluorescent antibody technique, used in one of our patients, helped in making the differentiation between primary lesion and metastatic disease. Diagnosis of prostatic carcinoma metastatic to breast carries a poor prognosis, and may be an indication for aggressive therapy.
临床上诊断为前列腺癌乳腺转移的情况较为罕见。前列腺原发性癌患者同时患有原发性乳腺癌的情况也不常见。本文描述了4例在前列腺癌病程中出现乳腺恶性肿瘤的患者。除1例患者外，其余患者均有弥漫性转移疾病。其中3例在乳腺恶性肿瘤被诊断时正在接受雌激素治疗。在临床和组织病理学上，区分原发性病变和转移瘤总是存在困难。我们对1例患者使用了酸性磷酸酶组织化学方法及最新的间接免疫荧光抗体技术，这有助于鉴别原发性病变和转移性疾病。前列腺癌转移至乳腺的诊断预后较差，可能提示需采取积极治疗。
