Necrotizing lesions in Sjögren's syndrome. II. An electron microscopic study.

Further evidences about necrotizing lesions in Sjögren's syndrome are presented. Electron microscopic studies disclosed acinar replacement by a mucus-containing lake surrounded by remnant myoepithelial cells. Interepithelial lymphocytes infiltrate the acinar walls in adjacent areas and macrophages bearing mucoid material within cytopasmic vacuoles were found in the interstitium. The significance of these findings in the natural history of Sjögren's syndrome is discussed.