Holstein B, Humphrey C S
Acta Physiol Scand. 1980 Jun;109(2):217-23. doi: 10.1111/j.1748-1716.1980.tb06589.x.
Cods were equipped with cannulae for drainage of the stomach and for separate perfusion of the stomach (pure sea-water) and intestine (diluted sea-water). Acidity and volume of gastric effluence were measured. Plasma immunoreactive gastrin and vasoactive intestinal polypeptide (VIP) were assayed in some experiments. The high rate of "basal" acid secretion was further elevated by i.m. administration of bombesin, but not by pentagastrin. Exogenous VIP inhibited acid secretion. Following 5 h of bombesin infusion, plasma gastrin-IR was unaffected while VIP-IR was depressed compared to saline-treated controls. The possibility that bombesin stimulates acid secretion by inhibiting VIP-release is discussed.
鳕鱼被安装了用于胃引流以及分别对胃（纯海水）和肠（稀释海水）进行灌注的套管。测量了胃酸分泌量和胃酸度。在一些实验中测定了血浆免疫反应性胃泌素和血管活性肠肽（VIP）。肌肉注射蛙皮素可进一步提高“基础”胃酸分泌率，但五肽胃泌素则无此作用。外源性VIP可抑制胃酸分泌。在输注蛙皮素5小时后，与生理盐水处理的对照组相比，血浆胃泌素免疫反应性未受影响，而VIP免疫反应性降低。文中讨论了蛙皮素通过抑制VIP释放来刺激胃酸分泌的可能性。
