肝脏胞质醛脱氢酶在DBA和C57Bl小鼠乙醇代谢中的作用。

The role of liver cytosolic aldehyde dehydrogenase in ethanol metabolism in DBA and C57Bl mice.

作者信息

Smolen A, Atkinson N, Petersen D R

出版信息

Adv Exp Med Biol. 1980;132:627-34. doi: 10.1007/978-1-4757-1419-7_65.

Abstract

Cytosolic aldehyde dehydrogenase (AlDH) activity was increased in DBA and C57Bl mice following phenobarbital (Pb) treatment. The kinetic constants for the control and induced enzymes were similar in both inbred strains. The DBA mice showed enhanced rates of ethanol and acetaldehyde metabolism after Pb treatment, whereas the C57Bl mice did not. It was concluded that the cytosolic enzyme is more important for acetaldehyde metabolism in the DBA than in the C57Bl mice.

摘要

苯巴比妥（Pb）处理后，DBA和C57Bl小鼠的胞质醛脱氢酶（AlDH）活性增加。在这两个近交系中，对照酶和诱导酶的动力学常数相似。Pb处理后，DBA小鼠的乙醇和乙醛代谢速率提高，而C57Bl小鼠则没有。得出的结论是，胞质酶对DBA小鼠乙醛代谢的重要性高于C57Bl小鼠。