胞质大鼠肝脏乙醛脱氢酶在体内乙醇代谢过程中乙醛氧化中的作用。
Role of cytosolic rat liver aldehyde dehydrogenase in the oxidation of acetaldehyde during ethanol metabolism in vivo.
作者信息
Eriksson C J, Marselos M, Koivula T
出版信息
Biochem J. 1975 Dec;152(3):709-12. doi: 10.1042/bj1520709.
Abstract
The activity of a high-Km aldehyde dehydrogenase in the liver cytosol was increased by phenobarbital induction. No corresponding increase in the oxidation rate of acetaldehyde in vivo was found, and it is concluded that cytosolic aldehyde dehydrogenase plays only a minor role in the oxidation of acetaldehyde during ethanol metabolism.
摘要
苯巴比妥诱导可增加肝细胞溶质中高 Km 醛脱氢酶的活性。但未发现体内乙醛氧化速率有相应增加，由此得出结论，在乙醇代谢过程中，细胞溶质醛脱氢酶在乙醛氧化中仅起次要作用。
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本文引用的文献
1
[On the metabolite content and the metabolite concentration in the liver of the rat].
Biochem Z. 1959;332:18-46.
2
Micro method for determination of ketone bodies by head-space gas chromatography.
Anal Biochem. 1972 May;47(1):235-43. doi: 10.1016/0003-2697(72)90297-7.
3
Enhancement of D-glucuronolactone and acetaldehyde dehydrogenase activities in the rat liver by inducers of drug metabolism.
Biochem Pharmacol. 1974 May 15;23(10):1457-66. doi: 10.1016/0006-2952(74)90383-9.
4
Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference.
Biochem Pharmacol. 1973 Sep 15;22(18):2283-92. doi: 10.1016/0006-2952(73)90009-9.
5
Genetic influence upon phenobarbital-induced increase in rat liver supernatant aldehyde dehydrogenase activity.
J Biol Chem. 1972 Nov 25;247(22):7232-6.
6
Genetic aspects of increase in rat liver aldehyde dehydrogenase induced by phenobarbital.
Science. 1971 Jul 23;173(3994):334-6. doi: 10.1126/science.173.3994.334.
7
Intracellular localization of aldehyde dehydrogenase in rat liver.
Biochem J. 1972 May;127(4):633-9. doi: 10.1042/bj1270633.
8
Utilization and metabolic effects of acetaldehyde and ethanol in the perfused rat liver.
Biochem J. 1972 Feb;126(4):945-52. doi: 10.1042/bj1260945.
9
Induction of liver acetaldehyde dehydrogenase: possible role in ethanol tolerance after exposure tobarbiturates.
Science. 1971 Jan 29;171(3969):387-9. doi: 10.1126/science.171.3969.387.
10
Tissue and subcellular distribution of mammalian aldehyde-oxydizing capacity.
Biochem Pharmacol. 1966 Dec;15(12):1911-22. doi: 10.1016/0006-2952(66)90220-6.
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