Hassold T J
Am J Hum Genet. 1980 Sep;32(5):723-30.
During a cytogenetic study of spontaneous abortions, successive abortions from 40 couples were karyotyped. The chromosome constitutions of the first and second abortions were found to be highly correlated. In each of 21 instances in which the first abortion was chromosomally normal, the subsequent abortion(s) was normal as well. In nine cases, the two abortions were chromosomally abnormal, and in four of these, both abortions were trisomic. Combined with findings from other studies of consecutive spontaneous abortions, the present data indicate that certain couples are at an increased risk for either repeated chromosomally normal abortions or for repeated trisomic conceptions. The increased risk of trisomy does not seem to be restricted to a particular chromosome, and the magnitude of the risk increase appears to be independent of maternal age.
在一项关于自然流产的细胞遗传学研究中，对40对夫妇的连续流产胎儿进行了核型分析。发现第一次和第二次流产胎儿的染色体组成高度相关。在第一次流产胎儿染色体正常的21例中，随后的流产胎儿也正常。在9例中，两次流产胎儿染色体均异常，其中4例两次流产胎儿均为三体。结合其他关于连续自然流产的研究结果，目前的数据表明，某些夫妇反复出现染色体正常流产或反复出现三体妊娠的风险增加。三体风险增加似乎不限于某一特定染色体，风险增加的幅度似乎与母亲年龄无关。
