反复自然流产的细胞遗传学研究。
A cytogenetic study of repeated spontaneous abortions.
作者信息
Hassold T J
出版信息
Am J Hum Genet. 1980 Sep;32(5):723-30.
Abstract
During a cytogenetic study of spontaneous abortions, successive abortions from 40 couples were karyotyped. The chromosome constitutions of the first and second abortions were found to be highly correlated. In each of 21 instances in which the first abortion was chromosomally normal, the subsequent abortion(s) was normal as well. In nine cases, the two abortions were chromosomally abnormal, and in four of these, both abortions were trisomic. Combined with findings from other studies of consecutive spontaneous abortions, the present data indicate that certain couples are at an increased risk for either repeated chromosomally normal abortions or for repeated trisomic conceptions. The increased risk of trisomy does not seem to be restricted to a particular chromosome, and the magnitude of the risk increase appears to be independent of maternal age.
摘要
在一项关于自然流产的细胞遗传学研究中，对40对夫妇的连续流产胎儿进行了核型分析。发现第一次和第二次流产胎儿的染色体组成高度相关。在第一次流产胎儿染色体正常的21例中，随后的流产胎儿也正常。在9例中，两次流产胎儿染色体均异常，其中4例两次流产胎儿均为三体。结合其他关于连续自然流产的研究结果，目前的数据表明，某些夫妇反复出现染色体正常流产或反复出现三体妊娠的风险增加。三体风险增加似乎不限于某一特定染色体，风险增加的幅度似乎与母亲年龄无关。
相似文献
1
A cytogenetic study of repeated spontaneous abortions.反复自然流产的细胞遗传学研究。
Am J Hum Genet. 1980 Sep;32(5):723-30.
2
Cytogenetic studies of couples with repeated spontaneous abortions of known karyotype.对已知核型的反复自然流产夫妇进行的细胞遗传学研究。
Genet Epidemiol. 1988;5(2):65-74. doi: 10.1002/gepi.1370050202.
3
4
Cytogenetic findings in 122 couples with recurrent abortions.122对复发性流产夫妇的细胞遗传学研究结果
Hum Genet. 1981;57(1):101-3. doi: 10.1007/BF00271179.
5
[Do chromosomal abnormalities reappear in subsequent pregnancies and how often?].[染色体异常在后续妊娠中会再次出现吗？出现的频率如何？]
Ginekol Pol. 2010 Sep;81(9):681-6.
6
The relationship of maternal age and trisomy among trisomic spontaneous abortions.三体性自然流产中母亲年龄与三体性的关系。
Am J Hum Genet. 1984 Nov;36(6):1349-56.
7
Successive spontaneous abortions with diverse chromosomal aberrations in human translocation heterozygote.人类易位杂合子中出现具有不同染色体畸变的连续自然流产。
Teratology. 1975 Dec;12(3):283-9. doi: 10.1002/tera.1420120310.
8
Skewed X chromosome inactivation and trisomic spontaneous abortion: no association.X染色体失活偏态与三体性自然流产：无关联。
Am J Hum Genet. 2009 Aug;85(2):179-93. doi: 10.1016/j.ajhg.2009.07.002. Epub 2009 Jul 30.
9
Reciprocal translocation with special reference to reproductive failure.特别是关于生殖失败的相互易位。
Hum Genet. 1980;55(3):303-7. doi: 10.1007/BF00290208.
10
[Karyological study of human spontaneous and medical abortions].[人类自然流产和人工流产的核型研究]
Tsitologiia. 1973 Jul;15(7):948-52.
引用本文的文献
1
Chromosome Abnormality Detection Rates of QF-PCR in Early Pregnancy Loss.孕早期流产中QF-PCR的染色体异常检测率
Curr Health Sci J. 2025 Jan-Mar;51(1):62-71. doi: 10.12865/CHSJ.51.01.06. Epub 2025 Mar 31.
2
Common variation in meiosis genes shapes human recombination phenotypes and aneuploidy risk.减数分裂基因的常见变异塑造了人类重组表型和非整倍体风险。
medRxiv. 2025 Apr 4:2025.04.02.25325097. doi: 10.1101/2025.04.02.25325097.
3
Aneuploidy confers a unique transcriptional and phenotypic profile to Candida albicans.非整倍体赋予白色念珠菌独特的转录和表型特征。
Nat Commun. 2025 Apr 6;16(1):3287. doi: 10.1038/s41467-025-58457-3.
4
Phenogenetics of cortical granule dynamics during zebrafish oocyte-to-embryo transition.斑马鱼卵母细胞向胚胎转变过程中皮质颗粒动力学的表型遗传学
Front Cell Dev Biol. 2025 Jan 30;13:1514461. doi: 10.3389/fcell.2025.1514461. eCollection 2025.
5
Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database.孕期药物暴露：一项基于初级保健数据库的病例对照研究。
Womens Health Rep (New Rochelle). 2024 Jan 11;5(1):13-21. doi: 10.1089/whr.2023.0123. eCollection 2024.
6
The number of prior pregnancy losses does not impact euploidy rates in young patients with idiopathic recurrent pregnancy loss.有不明原因复发性流产史的年轻患者，既往妊娠丢失次数并不影响胚胎非整倍体率。
Arch Gynecol Obstet. 2023 Nov;308(5):1567-1575. doi: 10.1007/s00404-023-07155-w. Epub 2023 Jul 19.
7
Stem Cell-Based Trophoblast Models to Unravel the Genetic Causes of Human Miscarriages.基于干细胞的滋养层细胞模型，以揭示人类流产的遗传原因。
Cells. 2022 Jun 14;11(12):1923. doi: 10.3390/cells11121923.
8
The impact of pre-evacuation ultrasound examination in histologically confirmed hydatidiform mole in missed abortion.超声检查在组织学确诊的过期流产合并葡萄胎中的作用。
BMC Womens Health. 2020 Sep 10;20(1):196. doi: 10.1186/s12905-020-01064-9.
9
Count data regression modeling: an application to spontaneous abortion.计数数据回归建模：在自然流产中的应用。
Reprod Health. 2020 Jul 8;17(1):106. doi: 10.1186/s12978-020-00955-2.
10
Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss.反复自然流产患者的核型分析：原发性和继发性复发性妊娠丢失。
J Assist Reprod Genet. 2020 Mar;37(3):517-525. doi: 10.1007/s10815-020-01703-y. Epub 2020 Feb 3.
本文引用的文献
1
THE NONRANDOMNESS OF CHROMOSOMAL ABNORMALITIES. ASSOCIATION OF TRISOMY 18 AND DOWN'S SYNDROME.染色体异常的非随机性。18三体与唐氏综合征的关联。
N Engl J Med. 1964 Nov 19;271:1081-6. doi: 10.1056/NEJM196411192712102.
2
The causes of mongolism.
Dan Med Bull. 1956 Aug;3(5):158-64.
3
Detection of higher recurrence risk for age-dependent chromosome abnormalities with an application to trisomy G1. (Down's syndrome).
Hum Hered. 1970;20(1):112-22. doi: 10.1159/000152301.
4
Aetiology of spontaneous abortion. A cytogenetic and epidemiological study of 288 abortuses and their parents.自然流产的病因学。对288例流产胎儿及其父母的细胞遗传学和流行病学研究。
Acta Obstet Gynecol Scand Suppl. 1976;52:1-29.
5
A cytogenetic study of spontaneous abortions in Hawaii.夏威夷自然流产的细胞遗传学研究。
Ann Hum Genet. 1978 May;41(4):443-54. doi: 10.1111/j.1469-1809.1978.tb00914.x.
6
Cytogenetics of aborters and abortuses.流产者与流产儿的细胞遗传学
Am J Obstet Gynecol. 1978 May 1;131(1):33-8. doi: 10.1016/0002-9378(78)90470-2.
7
Habitual abortion.习惯性流产
Fertil Steril. 1978 Mar;29(3):257-65. doi: 10.1016/s0015-0282(16)43149-3.
8
Previous reproductive history in mothers presenting with spontaneous abortions.有自然流产史母亲的既往生育史。
Br J Obstet Gynaecol. 1975 May;82(5):366-73. doi: 10.1111/j.1471-0528.1975.tb00651.x.
Zotero 插件