通过对基因型和表型频率进行卡方检验来检测近亲繁殖效应。
Detection of inbreeding effects by the chi-square test on genotypic and phenotypic frequencies.
作者信息
Haber M
出版信息
Am J Hum Genet. 1980 Sep;32(5):754-60.
Abstract
The problem of detection of inbreeding effects by the chi-square goodness-of-fit test is investigated. The noncentrality parameter of the limiting chi-square distribution is considered as a function of the inbreeding coefficient in two models: (1) a gene locus with m codominant alleles and (2) the generalized ABO model. Previous results by Ward and Sing and by Chakraborty and Rao were based on inadequate statistical reasoning. In the first model, the resulting noncentrality parameter is identical with that found by Ward and Sing. For the second model, the limiting noncentrality parameter is found to be zero.
摘要
研究了通过卡方拟合优度检验检测近亲繁殖效应的问题。在两个模型中，将极限卡方分布的非中心参数视为近亲繁殖系数的函数：（1）具有m个共显性等位基因的基因座和（2）广义ABO模型。沃德和辛以及恰克拉波蒂和拉奥之前的结果基于不充分的统计推理。在第一个模型中，得到的非中心参数与沃德和辛发现的相同。对于第二个模型，极限非中心参数被发现为零。
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引用本文的文献
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本文引用的文献
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Estimation of the inbreeding coefficient from ABO blood-group gene frequencies.根据ABO血型基因频率估算近亲繁殖系数
Am J Hum Genet. 1970 Jan;22(1):112-3.
2
Some methods of estimating the inbreeding coefficient.一些估计近亲繁殖系数的方法。
Am J Hum Genet. 1953 Jun;5(2):107-17.
3
Estimation of the inbreeding coefficient from phenotype frequencies by a method of maximum likelihood scoring.通过最大似然评分法从表型频率估计近亲繁殖系数。
Biometrics. 1968 Dec;24(4):915-35.
4
A gene-counting method of maximum likelihood for estimating gene frequencies in ABO and ABO-like systems.一种用于估计ABO及类ABO系统中基因频率的最大似然基因计数法。
Ann Hum Genet. 1968 May;31(4):409-20. doi: 10.1111/j.1469-1809.1968.tb00574.x.
5
Estimation of the inbreeding coefficient from ABO blood-group phenotype frequencies.根据ABO血型表型频率估算近亲繁殖系数
Am J Hum Genet. 1971 Jan;23(1):97-8.
6
Detection of the inbreeding coefficient from ABO blood-group data.从ABO血型数据中检测近亲繁殖系数。
Am J Hum Genet. 1972 May;24(3):352-4.
7
The generalized Wright's model and population structure with special reference to the ABO blood group system.广义赖特模型与群体结构，特别提及ABO血型系统
Am J Hum Genet. 1974 Jul;26(4):444-53.
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