Gerson M C, McHenry P L
Am J Med. 1980 Oct;69(4):545-50. doi: 10.1016/0002-9343(80)90465-9.
Resting 12-lead electrocardiographic records from 849 patients who underwent coronary cineangiographic studies were reviewed for U wave negativity without knowledge of the clinical data or angiographic results. In order to evaluate U wave negativity as an independent electrocardiographic sign, patients with significant Q waves in the anterior leads were excluded from the final data analysis leaving 760 patients. Twenty-seven patients had U wave negativity in leads I, aVL or V4 through V6. For the study population, the prevalence of coronary artery disease was 64 percent (484 or 760); the prevalence of significant left anterior descending or left main coronary artery stenosis was 46 percent (350 of 760); and the prevalence of angiographic left ventricular dysfunction was 41 percent (309 of 754). Among 27 patients with resting U wave negativity the prevalence of coronary artery disease was 89 percent (24 of 27); the prevalence of left anterior descending or left main disease was 89 percent (24 of 27); and the prevalence of angiographic left ventricular dysfunction was 80 percent (20 of 25). Among patients selected for coronary cineangiographic study, U wave negativity was a significant predictor (p < 0.001) of greater than or equal to 75 percent stenosis of the left anterior descending or left main coronary artery and of left ventricular dysfunction (p < 0.001).
回顾了849例接受冠状动脉造影研究患者的静息12导联心电图记录，以确定U波倒置情况，且不知晓临床数据或血管造影结果。为了评估U波倒置作为一项独立的心电图征象，前壁导联有显著Q波的患者被排除在最终数据分析之外，最终纳入760例患者。27例患者在I、aVL或V4至V6导联出现U波倒置。对于研究人群，冠状动脉疾病患病率为64%（760例中的484例）；左前降支或左主干冠状动脉显著狭窄的患病率为46%（760例中的350例）；血管造影显示左心室功能障碍的患病率为41%（754例中的309例）。在27例静息时出现U波倒置的患者中，冠状动脉疾病患病率为89%（27例中的24例）；左前降支或左主干病变的患病率为89%（27例中的24例）；血管造影显示左心室功能障碍的患病率为80%（25例中的20例）。在入选冠状动脉造影研究的患者中，U波倒置是左前降支或左主干冠状动脉≥75%狭窄以及左心室功能障碍的显著预测指标（p<0.001）。
