Vikram B, Strong E W, Shah J, Spiro R H
Am J Surg. 1980 Oct;140(4):580-4. doi: 10.1016/0002-9610(80)90217-2.
One hundred five patients with advanced (American Joint Committee stages III and IV) but resectable epidermoid carcinoma of the head and neck were treated with radical surgery and elective postoperative radiation therapy. Follow-up periods range from 16 to 66 months. Nineteen patients (18 percent) have had recurrence in the head and neck area. This is better than our past experience with surgical treatment alone in advanced head and neck cancer, in which 50 to 75 percent of patients had local recurrence within the 1st 18 months. When radiation therapy was started no later than 6 weeks after surgery, only 3 of 54 patients (5.5 percent) had local recurrence, but when there was a longer delay 16 of 51 patients (31.5 percent) had recurrence. These results suggest that elective postoperative radiation therapy improves local control in patients with advanced head and neck cancer, but that it should be delivered soon after surgery for maximum effectiveness.
105例患有晚期（美国联合委员会III期和IV期）但可切除的头颈部表皮样癌患者接受了根治性手术及选择性术后放疗。随访期为16至66个月。19例患者（18%）出现头颈部区域复发。这比我们过去单纯手术治疗晚期头颈部癌的经验要好，在过去的经验中，50%至75%的患者在最初18个月内出现局部复发。当放疗在手术后不迟于6周开始时，54例患者中只有3例（5.5%）出现局部复发，但当延迟时间更长时，51例患者中有16例（31.5%）出现复发。这些结果表明，选择性术后放疗可改善晚期头颈部癌患者的局部控制，但为达到最大疗效，应在手术后尽快进行放疗。
