Berman E J, Shie M D, Rowe G A
Am Surg. 1980 Oct;46(10):582-8.
Fifty children with gangrenous appendicitis were treated consecutively by appendectomy followed by saline irrigation and loose wound closure. Drainage was not employed. Ampicillin and oxacillin were mixed and given intravenously. In 28 of 50 patients, ampicillin powder was dusted into the wound. No intraperitoneal complications occurred. Seven would infections required incision. Dusting ampicillin powder into the wound reduced this complication to less than 10 per cent. Four patients had nasogastric tubes. The usual hospital stay was three to eight days. The most common organisms cultured were Escherichia coli (68%), Streptococcus species (60%), and anaerobic species (48%). Eleven patients were evaluated for synergism between ampicillin and oxacillin. Eight showed some evidence of synergism in that the minimal inhibitory concentration (MIC) of the combination was less than the MIC of the individual drugs.
五十名患有坏疽性阑尾炎的儿童连续接受了阑尾切除手术，随后用生理盐水冲洗并松散缝合伤口，未进行引流。将氨苄青霉素和苯唑西林混合后静脉注射。在50名患者中的28名患者中，将氨苄青霉素粉末撒入伤口。未发生腹腔内并发症。七例伤口感染需要切开。向伤口撒氨苄青霉素粉末使这种并发症减少到不到10%。四名患者使用了鼻胃管。通常的住院时间为三到八天。培养出的最常见病原体为大肠杆菌（68%）、链球菌属（60%）和厌氧菌（48%）。对11名患者评估了氨苄青霉素和苯唑西林之间的协同作用。八名患者显示出一些协同作用的证据，即联合用药的最低抑菌浓度（MIC）低于各单一药物的MIC。
