Pershin G N
Antibiotiki. 1980 Oct;25(10):723-9.
Chemotherapy and chemoprophylaxis play a significant role in control of various infectious diseases. The use of chemotherapeutic drugs is associated with a number of difficulties, such as development of drug resistance in pathogenic microorganism during the treatment, possible toxic effects of drugs on their prolonged use, inefficiency of chemotherapy in bacteria carriers, etc. In spite of the achievements in chemotherapy of acute bacterial infections, tuberculosis, lepra, mycoses, protozoal infections, it is necessary to have available new drugs for the treatment of these diseases. The achievements in chemotherapy of viral infections are relatively modest. However, therapy of such infections is of great importance for medicine. Highly effective broad-spectrum antiviral agents may play a significant role in the control of widely spread viral diseases of man and cattle. Such drugs will be of great significance in prevention of complications in persons with viral infections and studying the diseases of supposed viral etiology. For the successful solution of the problems of chemotherapy, a proper strategy in the development of the research work in this field is of importance.
化疗和化学预防在控制各种传染病方面发挥着重要作用。化疗药物的使用存在诸多困难，例如治疗期间致病微生物会产生耐药性、长期使用药物可能产生毒性作用、化疗对细菌携带者无效等。尽管在急性细菌感染、结核病、麻风病、真菌病、原生动物感染的化疗方面取得了成就，但仍需要有新的药物来治疗这些疾病。病毒感染的化疗成果相对较少。然而，此类感染的治疗对医学至关重要。高效广谱抗病毒药物可能在控制人类和牛群中广泛传播的病毒性疾病方面发挥重要作用。此类药物在预防病毒感染患者的并发症以及研究假定病毒病因的疾病方面具有重要意义。为了成功解决化疗问题，在该领域开展研究工作时制定适当的策略至关重要。
