Hernández O, Frenk S, Velasco-Candano L, Urrusti J, Yoshida P, Bernal-Torres A, Rosado A
Arch Invest Med (Mex). 1980;11(2):175-86.
The basal and stimulated metabolism of leukocytes obtained from fetally malnourished and normal children was comparatively studied. All basal activities of the leukocytes from malnourished children were significantly lower than those observed in normal children: Glucose-6-P-deydrogenase activity was 1.04 +/- 0.12 against 1.27 +/- 0.22 mumoles/min/10(8) cells; leukocyte-oxidase activity was 0.19 +/- 0.03 against 0.31 +/- 0.05 OD units/15 min/2.5 x 10(6) cells, oxygen uptake was 384 +/- 48 against 728 +/- 103 nmoles 0(2)/hr/10(8) cells. The conversion of glucose -1(14)C to 14CO2 was 83 +/- 10 nmoles/10(8) cells in malnourished children and 134 +/- 22 in controls. The response of all the parameters studied to the stimulation of phagocytosis was also significantly lower in fetally malnourished than in control babies.
对从胎儿期营养不良和正常儿童获取的白细胞的基础代谢和刺激后代谢进行了比较研究。营养不良儿童白细胞的所有基础活性均显著低于正常儿童：葡萄糖-6-磷酸脱氢酶活性为1.04±0.12，而正常儿童为1.27±0.22微摩尔/分钟/10⁸个细胞；白细胞氧化酶活性为0.19±0.03，而正常儿童为0.31±0.05光密度单位/15分钟/2.5×10⁶个细胞，氧摄取量为384±48，而正常儿童为728±103纳摩尔O₂/小时/10⁸个细胞。营养不良儿童中葡萄糖-1-(¹⁴)C转化为¹⁴CO₂的量为83±10纳摩尔/10⁸个细胞，对照组为134±22。与对照婴儿相比，胎儿期营养不良儿童的所有研究参数对吞噬作用刺激的反应也显著降低。
