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具有各种围产期风险的新生儿玻璃黏附外周血白细胞对镉微晶的吞噬作用。

Phagocytosis of cadmium microcrystals by glass-adherent peripheral blood leucocytes of newborns with various perinatal risks.

作者信息

Miler I, Procházková E, Borte M, Vondrácek J, Braun W

机构信息

Research Institute for the Care of Mother and Child, Prague, Czechoslovakia.

出版信息

Allerg Immunol (Leipz). 1987;33(4):231-7.

PMID:2964177
Abstract

Using cadmium microcrystals saturated with human serum albumin as particles for the phagocytic assay, the phagocytic activity of peripheral blood glass-adherent leucocytes of 32 preterm infants, 15 small-for-date newborns, 14 term newborns with perinatal asphyxia and 27 term newborns of diabetic mothers was compared with healthy term newborns and normal adults. A statistically significant increase in both the percent of phagocytosing cells and in the mean number of engulfed particles per cell was found in all groups of "stressed" infants as compared with cells of adults. No difference in the proportion of actively phagocytosing cells was found between term healthy and stressed neonates; as regards the mean number of ingested particles per cell, a slight increase (however, statistically not significant) was found in all groups of infants with perinatal risks compared with normal infants suggesting a temporary stimulation of these cells.

摘要

以饱和人血清白蛋白的镉微晶作为吞噬试验的颗粒,比较了32例早产儿、15例小于胎龄儿、14例围产期窒息足月儿和27例糖尿病母亲所生足月儿的外周血玻璃黏附白细胞的吞噬活性,并与健康足月儿和正常成年人进行了对比。与成年人的细胞相比,在所有“应激”婴儿组中,吞噬细胞的百分比和每个细胞吞噬颗粒的平均数均有统计学意义的增加。足月健康新生儿和应激新生儿之间在活跃吞噬细胞的比例上未发现差异;就每个细胞摄取颗粒的平均数而言,与正常婴儿相比,所有有围产期风险的婴儿组均有轻微增加(然而,无统计学意义),提示这些细胞受到暂时刺激。

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