Olson R J, Kolodner H, Morgan K S, Escapini H, Sevel D, Kaufman H E
Arch Ophthalmol. 1980 Oct;98(10):1840-2. doi: 10.1001/archopht.1980.01020040692019.
Sixty-eight intraocular lenses were implanted in cats to compare the efficacy of a new polyvinyl alcohol coating in protecting the corneal endothelium from lens-cell contact damage. The mean endothelial density after implantation of the coated lens was significantly higher than the cell density in those eyes receiving the uncoated lens. We saw no clinical signs of unusual inflammation; whole-eye histopathologic study disclosed no signs of inflammation or toxicity related to the coating. Ten coated lenses were placed in balanced salt solution or perfused with balanced salt solution at 0.5 mL/min. The coating remained intact for 60 minutes, affording corneal endothelial protection for this period. In a rabbit anterior chamber toxicity study, using balanced salt solution as a control, no differencs in reaction in the anterior chamber or intraocular pressure were noted.
为比较一种新型聚乙烯醇涂层在保护角膜内皮免受晶状体细胞接触损伤方面的效果，在猫眼中植入了68枚人工晶状体。植入涂层晶状体后的平均内皮细胞密度显著高于植入未涂层晶状体的眼睛中的细胞密度。我们未观察到异常炎症的临床迹象；全眼球组织病理学研究未发现与涂层相关的炎症或毒性迹象。将10枚涂层晶状体置于平衡盐溶液中或以0.5毫升/分钟的速度用平衡盐溶液灌注。涂层在60分钟内保持完整，在此期间为角膜内皮提供了保护。在一项兔眼前房毒性研究中，以平衡盐溶液作为对照，未观察到前房反应或眼压存在差异。
