Kennaway D J, Seamark R F
Aust J Biol Sci. 1980 Jun;33(3):349-53. doi: 10.1071/bi9800349.
The effect of differing doses and routes of administration of melatonin on plasma melatonin levels in sheep and goats has been examined. Melatonin injected subcutaneously in a saline or oil vehicle caused high transitory peaks in plasma melatonin whereas oral administration, in either saline solution or adsorbed onto pelleted foodstuff, resulted in sustained elevated blood levels for periods exceeding 7 h. Oral dosages of about 2 mg proved adequate to raise the normal daytime plasma levels in both sheep and goats to levels within the normal night-time range. It was concluded that with ruminants the oral route of administration provides a convenient and practical way of administering melatonin for physiological study.
已研究了不同剂量和给药途径的褪黑素对绵羊和山羊血浆褪黑素水平的影响。用生理盐水或油剂载体皮下注射褪黑素会导致血浆褪黑素出现短暂的高峰，而口服（溶于生理盐水或吸附在颗粒状食物上）则会使血液水平持续升高超过7小时。约2毫克的口服剂量足以将绵羊和山羊正常白天的血浆水平提高到正常夜间范围内。得出的结论是，对于反刍动物，口服给药途径为生理研究提供了一种方便实用的褪黑素给药方式。
