Kane M A, Johnson A, Nash A E, Boose D, Mathai G, Balmer C, Yohn J J, Robinson W A
Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262.
Melanoma Res. 1994 Feb;4(1):59-65. doi: 10.1097/00008390-199402000-00009.
The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma. Hourly blood samples were obtained from five patients for 24 h prior to melatonin administration and for 24 h during oral administration of melatonin, 50 mg every 4 h. In two of the five patients, the expected nocturnal plasma melatonin peak was observed. Oral melatonin was well absorbed. Plasma melatonin levels exhibited six peaks and troughs, were two to four-fold higher during peaks than troughs, and remained more than 25 times higher than peak pretreatment melatonin levels, even during troughs. Divided oral doses of melatonin were well tolerated and maintained plasma melatonin levels 25-80 times higher than endogenous peak values.
本研究的目的是确定分次口服褪黑素对转移性黑色素瘤患者血浆褪黑素水平的影响。在给予褪黑素前24小时及口服褪黑素（每4小时50毫克）期间的24小时内，每小时从5名患者采集血样。在5名患者中的2名观察到了预期的夜间血浆褪黑素峰值。口服褪黑素吸收良好。血浆褪黑素水平呈现出6个峰谷，峰值比谷值高2至4倍，即使在谷值时也比预处理前的褪黑素峰值水平高25倍以上。分次口服褪黑素耐受性良好，使血浆褪黑素水平维持在内源性峰值的25至80倍以上。
