牛神经鞘瘤中病毒样颗粒的研究。

A study of virus-like particles present in bovine nerve sheath tumours.

作者信息

Canfield P J, Doughty F R

出版信息

Aust Vet J. 1980 Jun;56(6):257-61. doi: 10.1111/j.1751-0813.1980.tb05718.x.

DOI:10.1111/j.1751-0813.1980.tb05718.x

Abstract

The morphology of virus-like particles present in bovine nerve sheath tumours is described, and their origin and significance discussed. Virus-like particles were investigated using transmission electron microscopy and tissue culture. The particles were found in a number of tumours and were present either as aggregates in pseudonuclear inclusions or as budding forms associated with the plasma membrane. The latter were found only in cultured tissue. Although other cellular structures were considered it was thought that the particles represented virus, with those in pseudonuclear inclusions being an intermediate form. Both bovine syncytial virus and oncovirinae were considered as possibilities in the aetiology of the condition.

摘要

描述了牛神经鞘瘤中存在的病毒样颗粒的形态，并讨论了它们的起源和意义。使用透射电子显微镜和组织培养对病毒样颗粒进行了研究。在许多肿瘤中发现了这些颗粒，它们要么以假核内的聚集体形式存在，要么以与质膜相关的出芽形式存在。后者仅在培养组织中发现。尽管考虑了其他细胞结构，但认为这些颗粒代表病毒，假核内的颗粒为中间形式。牛合胞体病毒和肿瘤病毒科都被认为是该病病因的可能因素。