Koschinsky T, Bünting C E, Schwippert B, Gries F A
Atherosclerosis. 1980 Oct;37(2):311-7. doi: 10.1016/0021-9150(80)90017-9.
Serum factors from non-ketotic poorly controlled diabetic patients when compared to serum factors from normal subjects, stimulate growth and protein synthesis of cultured fibroblasts from diabetic patients by 25-50%. This increased growth stimulating effect of diabetic serum is mainly related to low molecular weight components (mol. wt. < 12,000 daltons), but not to insulin or glucose. These low molecular weight components of diabetic serum are effective only in combination with serum factors of a molecular weight > 12,000 daltons which are essential for initiation and continuous stimulation of cellular growth. As the growth stimulation by diabetic serum factors with a molecular weight < 12,000 daltons does not differ from comparable normal serum factors, the relevance of these serum factors (e.g. growth hormone, lipoproteins) for the increased growth stimulation of mesenchymal cells in diabetes mellitus seems to be only of limited importance. In as much as these in vitro results represent the in vivo situation, chronic exposure of vascular cells from diabetics to these serum factors could be related to the increased angiopathic risk in diabetes mellitus.
与正常受试者的血清因子相比，非酮症控制不佳的糖尿病患者的血清因子可使糖尿病患者培养的成纤维细胞的生长和蛋白质合成增加25% - 50%。糖尿病血清这种增强的生长刺激作用主要与低分子量成分（分子量< 12,000道尔顿）有关，而与胰岛素或葡萄糖无关。糖尿病血清的这些低分子量成分仅在与分子量> 12,000道尔顿的血清因子结合时才有效，后者对于启动和持续刺激细胞生长至关重要。由于分子量< 12,000道尔顿的糖尿病血清因子的生长刺激作用与相当的正常血清因子没有差异，这些血清因子（如生长激素、脂蛋白）对糖尿病中间充质细胞生长刺激增加的相关性似乎仅具有有限的重要性。就这些体外结果代表体内情况而言，糖尿病患者的血管细胞长期暴露于这些血清因子可能与糖尿病中血管病变风险增加有关。
