早期诊断性脾切除术对霍奇金病的预后影响：一项随机试验
Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.
作者信息
Askergren J, Björkholm M, Holm G, Johansson B, Mellstedt H, Sundblad R, Söderberg G
出版信息
Br J Cancer. 1980 Aug;42(2):284-91. doi: 10.1038/bjc.1980.228.
A randomized trial is reported which evaluates the effect of early diagnostic splenectomy on the prognosis of patients with Hodgkin's disease (HD) and uncertain prognosis. This was started in January 1973 and concluded in April 1979. Sixty-seven patients were entered in the study and 31 were randomized for splenectomy. All patients except 2 received total nodal irradiation, excluding the splenic and hepatic areas. After 40 months' observation there was no difference between the groups in respect of survival and the number of recurrences. However, relapses occurred earlier in the splenectomized patients. Pneumococcal septicaemia was recorded in 2 splenectomized patients. It is concluded that prognosis is not improved by diagnostic splenectomy in HD patients with uncertain prognosis and treated with total nodal irradiation.
报告了一项随机试验，该试验评估了早期诊断性脾切除术对霍奇金病（HD）且预后不确定患者预后的影响。该试验于1973年1月开始，1979年4月结束。67例患者进入研究，31例被随机分配接受脾切除术。除2例患者外，所有患者均接受了全淋巴结照射，脾区和肝区除外。经过40个月的观察，两组在生存率和复发次数方面没有差异。然而，脾切除患者的复发出现得更早。2例脾切除患者记录到肺炎球菌败血症。得出的结论是，对于预后不确定且接受全淋巴结照射治疗的HD患者，诊断性脾切除术并不能改善预后。
Zotero 插件