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热疗对正常及白血病淋巴细胞放射敏感性的影响。

Effects of hyperthermia on radiosensitivity of normal and leukaemic lymphocytes.

作者信息

Schrek R, Stefani S S

出版信息

Br J Exp Pathol. 1980 Jun;61(3):256-60.

PMID:7426381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041584/
Abstract

We measured the effects of X-irradiation plus incubation at elevated temperatures on peripheral blood lymphocytes from normal persons and from patients with chronic lymphocytic leukaemia. Counts of viable lymphocytes were based on morphological characteristics by phase microscopy. Dose-effect curves for X-irradiation were biphasic. The D0S for lymphocytes incubated at 39 and 41 degrees were significantly less than the D0 for 37 degrees. For both normal and leukaemia lymphocytes, X-irradiation was synergistic with hyperthermia at 39 degrees and 41 degrees.

摘要

我们测量了X射线照射以及在高温下孵育对正常人和慢性淋巴细胞白血病患者外周血淋巴细胞的影响。活淋巴细胞计数基于相差显微镜下的形态学特征。X射线照射的剂量效应曲线呈双相性。在39℃和41℃孵育的淋巴细胞的D0S显著低于37℃时的D0。对于正常淋巴细胞和白血病淋巴细胞，在39℃和41℃时，X射线照射与热疗具有协同作用。

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本文引用的文献

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Clinical evaluation of an in vitro test for radiosensitivity of leukemic lymphocytes.白血病淋巴细胞放射敏感性体外检测的临床评估
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Sensitivity of normal and leukemic lymphocytes and leukemic myeloblasts to heat.正常淋巴细胞、白血病淋巴细胞及白血病成髓细胞对热的敏感性。
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6
The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.热疗和美法仑对人成纤维细胞株和黑色素瘤细胞系存活率的影响。
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Prospects for hyperthermia in human cancer therapy. Part II: implications of biological and physical data for applications of hyperthermia to man.人类癌症治疗中热疗的前景。第二部分：生物学和物理学数据对热疗在人体应用的影响。
Radiology. 1977 May;123(2):497-503. doi: 10.1148/123.2.497.
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Radiosensitivity of human lymphocytes and thymocytes.
Radiat Res. 1977 Jan;69(1):143-51.

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