Gange R W
Br J Dermatol. 1980 Jul;103(1):51-9. doi: 10.1111/j.1365-2133.1980.tb15837.x.
Neutrophil chemotaxis in the presence of tetracycline and clindamycin was evaluated using an agarose technique. No significant inhibition of chemotaxis by these antibiotics could be demonstrated, in contrast to previously reported findings using the Boyden chamber technique for measurement of chemotaxis. Both agents caused a minor increase in movement towards a P. acnes derived chemotactic factor. Some reduction of chemokinesis by high concentrations of tetracycline was noted. No effect of the drugs upon generation of chemotactic activity from whole serum could be demonstrated. Normal cell movement occurred in the absence of extracellular calcium and magnesium, in contrast to reported findings using the Boyden chamber.
采用琼脂糖技术评估了四环素和克林霉素存在下的中性粒细胞趋化性。与先前使用博伊登小室技术测量趋化性的报道结果相反，这些抗生素未显示出对趋化性的显著抑制作用。两种药物均使向痤疮丙酸杆菌衍生趋化因子的移动略有增加。注意到高浓度四环素会使细胞运动能力略有降低。未证明这些药物对全血清趋化活性的产生有影响。与使用博伊登小室的报道结果相反，在没有细胞外钙和镁的情况下，细胞正常移动。
