Chu A C, Hay R J, MacDonald D M
Br J Dermatol. 1980 Jul;103(1):95-100. doi: 10.1111/j.1365-2133.1980.tb15844.x.
A 31-year-old woman with long-standing renal disease, treated with systemic steroids and azathioprine, developed progressive skin ulceration and subcutaneous nodules. A diagnosis of cryptococcosis was established after histological examination of a cutaneous lesion and confirmed by culture of the organism from the biopsy specimen. A detailed description of the histology and ultrastructure of the cutaneous lesion is presented. Treatment with parenteral amphotericin B and 5-fluorocytosine resulted in dramatic resolution of the skin lesions.
一名31岁患有长期肾病的女性，接受全身类固醇和硫唑嘌呤治疗，出现了进行性皮肤溃疡和皮下结节。经皮肤病变组织学检查确诊为隐球菌病，并通过活检标本中该生物体的培养得到证实。本文详细描述了皮肤病变的组织学和超微结构。静脉注射两性霉素B和5-氟胞嘧啶治疗后，皮肤病变显著消退。
